Endocrine Abstracts

Thyroid hormones are evolutionarily conserved iodine-containing regulators of metabolism and development (reviewed by Mullur et al. (2014)). A key process in synthesis of the effectors thyroxine and tri-iodothyronine is the uptake of iodide from the bloodstream into thyroid follicular cells by the sodium-iodide symporter channel (NIS) encoded by the solute-carrier gene SLC5A5. Perturbation of NIS activity by environmental chemicals can lead to rapid and potent changes...

Regulators are concerned about the potential for environmental chemicals such as agrochemicals and their metabolites to perturb hormone systems. This has led to recommendations for the testing of potential endocrine disrupting chemicals1. The Steroidogenesis H295R assay is an in vitro cell model used to investigate compound effects on steroid hormone biosynthesis, specifically 17β-estradiol (E2) and testosterone (T). The human H295R adreno-carcinoma ce...